Professional
Technical
In the Industry Vocabulary Test
protamine
Pronunciation: PROH-tah-meen
Medication used to reverse heparin anticoagulation after cardiopulmonary bypass.
Full Definition
Protamine sulfate is a positively charged protein derived from fish sperm that neutralizes the anticoagulant effects of heparin by forming inactive complexes. It is routinely administered at the conclusion of cardiopulmonary bypass to restore normal coagulation function. Protamine administration requires careful monitoring as it can cause severe allergic reactions, pulmonary hypertension, and cardiovascular collapse in susceptible patients.
Usage
Usage note: Always specify 'protamine sulfate' in formal documentation
In Context
- "Protamine was administered in a 1:1 ratio to neutralize the residual heparin effect." — Medication administration record
Also known as
protamine sulfate
Contrasted with
heparin
Don't confuse with
prothrombin
protein