academic research consortium definitions
Also written as: ARC — Academic Research Consortium
Standardized clinical endpoint definitions developed to ensure consistency across cardiovascular device trials.
Full Definition
Academic Research Consortium (ARC) definitions represent internationally recognized standardized criteria for clinical endpoints in cardiovascular device research, developed through collaboration between academic institutions, regulatory agencies, and industry. These definitions provide precise, consistent criteria for adjudicating events such as myocardial infarction, stent thrombosis, bleeding complications, and composite endpoints in clinical trials. ARC definitions have evolved through multiple iterations (ARC-1, ARC-2, ARC-HBR) to address emerging clinical needs and incorporate advancing diagnostic technologies. The standardization ensures that study results can be compared across different trials and facilitates meta-analyses and regulatory decision-making. ARC definitions specify not only the clinical criteria for each endpoint but also the required documentation, timing considerations, and hierarchical classification systems. These definitions are widely adopted in pivotal device trials and have become the gold standard for cardiovascular research.
Usage
Usage note: Specify which version of ARC definitions is being used in study protocols.
In Context
- "All endpoints were adjudicated according to Academic Research Consortium definitions." — Clinical trial methodology
- "The study protocol adhered to the latest Academic Research Consortium definitions for device endpoints." — Protocol document