binary angiographic restenosis
Diameter stenosis of 50% or greater at follow-up angiography in a previously treated vessel segment.
Full Definition
Binary angiographic restenosis is defined as a diameter stenosis of 50% or greater at the target lesion site during follow-up angiography, typically performed 6-9 months after percutaneous coronary intervention. This dichotomous endpoint provides a standardized definition for restenosis that can be consistently applied across different studies and clinical settings. The 50% threshold was chosen based on physiological studies demonstrating that stenoses of this severity often correlate with ischemia during stress testing. Binary angiographic restenosis is considered an important surrogate endpoint in device evaluation studies, as it correlates with clinical outcomes and the need for repeat revascularization procedures. The measurement requires careful quantitative coronary angiography with appropriate calibration and standardized projection angles to ensure accurate assessment.
Usage
Usage note: Always specify the timing of follow-up angiography when reporting binary restenosis rates.
In Context
- "Binary angiographic restenosis occurred in 8.2% of lesions at 6-month follow-up." — Clinical trial results
- "The primary endpoint was binary angiographic restenosis at nine months." — Study protocol