device-oriented composite endpoint
Standardized composite outcome measure in cardiovascular device trials combining cardiac death, target vessel myocardial infarction, and target vessel revascularization.
Full Definition
The device-oriented composite endpoint (DOCE) is a standardized outcome measure specifically designed for cardiovascular device trials, particularly percutaneous coronary intervention studies. DOCE combines three components: cardiac death, target vessel myocardial infarction, and clinically-driven target vessel revascularization. This composite was developed to provide a device-specific assessment of safety and efficacy, focusing on events most likely related to the investigational device or procedure. The Academic Research Consortium has standardized DOCE definitions to enable consistent reporting and comparison across device trials, distinguishing it from broader patient-oriented composite endpoints that include non-cardiovascular events.
Usage
Usage note: Always specify the three components when first introducing; distinguish from patient-oriented outcomes.
In Context
- "The device-oriented composite endpoint occurred in 6.1% of patients treated with the novel stent system." — device trial results
- "Both trials used the standardized device-oriented composite endpoint to enable direct comparison of outcomes." — systematic review