device-related thrombosis
Blood clot formation specifically associated with implanted cardiac devices such as stents or mechanical valves.
Full Definition
Device-related thrombosis refers to the formation of blood clots on or around implanted cardiac devices, including coronary stents, mechanical heart valves, ventricular assist devices, and other implantable cardiovascular devices. This complication represents a major safety concern in cardiovascular research and is often included as a primary or secondary safety endpoint in device trials. The thrombosis can lead to device malfunction, embolization, or acute cardiovascular events. Risk factors include inadequate anticoagulation, device design characteristics, and patient-specific factors such as hypercoagulable states.
Usage
Usage note: Be specific about the type of device when reporting thrombotic events.
In Context
- "The primary safety endpoint included device-related thrombosis confirmed by imaging or autopsy." — Clinical trial endpoints
- "Two patients experienced device-related thrombosis despite optimal anticoagulation therapy." — Results section