FFR
Also written as: FFR — Fractional Flow Reserve
Hemodynamic measurement assessing the functional significance of coronary stenosis during maximal hyperemia.
Full Definition
Fractional Flow Reserve (FFR) is a physiological measurement that determines the hemodynamic significance of coronary artery stenosis by calculating the ratio of distal coronary pressure to aortic pressure during maximal hyperemia, typically induced by adenosine. An FFR value ≤0.80 indicates functionally significant stenosis requiring revascularization, while values >0.80 suggest defer intervention. In cardiovascular research, FFR-guided revascularization strategies have been extensively studied, demonstrating improved outcomes compared to angiography-guided approaches. FFR measurement requires a pressure wire and pharmacological vasodilation, making it distinct from anatomical assessments alone.
Usage
Usage note: Always specify the threshold value (0.80) when discussing clinical decision-making.
In Context
- "FFR-guided PCI was associated with reduced rates of unnecessary revascularization procedures." — clinical trial manuscript
- "The lesion demonstrated 70% angiographic stenosis but FFR was 0.85, indicating deferral of intervention." — case report