fractional flow reserve
Also written as: FFR — Fractional flow reserve
Invasive physiologic measurement comparing distal coronary pressure to aortic pressure during maximal hyperemia to assess lesion significance.
Full Definition
Fractional flow reserve (FFR) is a lesion-specific index of the functional significance of a coronary stenosis, calculated as the ratio of distal coronary pressure to aortic pressure during pharmacologically induced maximum hyperemia. FFR values ≤0.80 typically indicate hemodynamically significant stenosis requiring intervention. In cardiovascular research, FFR-guided therapy has been shown to improve clinical outcomes compared to angiography-guided decisions alone. Studies often compare FFR-guided versus angiography-guided revascularization strategies. Editors should ensure that FFR thresholds and measurement protocols are clearly specified in methodology sections.
Usage
Usage note: Specify threshold values (typically 0.80) and hyperemic agent used. Distinguish from instantaneous wave-free ratio (iFR).
In Context
- "FFR-guided PCI resulted in fewer stents placed compared to angiography-guided procedures." — Physiologic assessment study
- "Lesions with FFR >0.80 were managed medically according to protocol specifications." — Clinical decision-making trial