HFpEF
Also written as: HFpEF — Heart Failure with preserved Ejection Fraction
Heart failure with preserved ejection fraction, a clinical syndrome characterized by symptoms of heart failure despite normal or near-normal left ventricular ejection fraction.
Full Definition
Heart failure with preserved ejection fraction (HFpEF) represents approximately 50% of all heart failure cases and poses unique therapeutic challenges. Patients typically have ejection fractions ≥50% but demonstrate impaired diastolic function, increased filling pressures, and reduced exercise capacity. The condition is more common in elderly patients, women, and those with comorbidities like hypertension and diabetes. Research in HFpEF has been particularly challenging due to the heterogeneous nature of the syndrome and lack of proven therapies that reduce mortality.
Usage
Usage note: Use 'HFpEF' in abbreviated form after first mention; maintain consistent capitalization.
In Context
- "The primary endpoint was cardiovascular death or hospitalization for heart failure in patients with HFpEF." — Clinical trial design
- "Enrollment criteria included symptomatic HFpEF with LVEF ≥45% and elevated NT-proBNP levels." — Study protocol