HFrEF
Also written as: HFrEF — Heart failure with reduced ejection fraction
Heart failure with reduced ejection fraction, defined as ejection fraction ≤40% with signs and symptoms of heart failure.
Full Definition
Heart failure with reduced ejection fraction (HFrEF) is a clinical syndrome characterized by impaired left ventricular systolic function (ejection fraction ≤40%) accompanied by signs and symptoms of heart failure. This classification has largely replaced the older term 'systolic heart failure' in contemporary cardiovascular research. HFrEF patients typically benefit from evidence-based therapies including ACE inhibitors, beta-blockers, and aldosterone antagonists. Editors should distinguish HFrEF from HFpEF (preserved ejection fraction) and HFmrEF (mildly reduced ejection fraction) in manuscript reviews.
Usage
Usage note: Always define on first use. Ensure EF threshold (typically ≤40%) is specified in study populations.
In Context
- "The study population comprised 1,200 patients with symptomatic HFrEF and EF ≤35%." — Heart failure clinical trial
- "HFrEF patients demonstrated significant improvement in 6-minute walk distance following treatment." — Therapeutic intervention study