in-stent restenosis
Also written as: ISR — In-stent restenosis
Re-narrowing of a coronary artery within or adjacent to a previously implanted stent, typically defined as >50% diameter stenosis.
Full Definition
In-stent restenosis (ISR) is the re-narrowing of a coronary artery segment within or immediately adjacent to a previously placed stent, usually defined as >50% diameter stenosis on angiography. This complication results from neointimal hyperplasia in response to vessel injury and foreign body reaction. Drug-eluting stents significantly reduced ISR rates compared to bare metal stents, from approximately 20-30% to <10%. In cardiovascular research, ISR serves as a key safety endpoint for device trials and a target for novel therapeutic approaches. Editors should verify that ISR definitions, timing of assessment, and measurement methods are clearly specified in stent-related studies.
Usage
Usage note: Hyphenate when used as compound adjective. Specify stenosis threshold (typically 50%) and assessment timepoint.
In Context
- "Angiographic in-stent restenosis at 9 months occurred in 8.2% of drug-eluting stent patients." — Stent efficacy trial
- "Treatment of in-stent restenosis with drug-coated balloons showed promising results." — Device innovation study