target lesion failure
Composite endpoint encompassing cardiac death, target vessel myocardial infarction, or target lesion revascularization, focusing on lesion-specific outcomes.
Full Definition
Target lesion failure (TLF) is a composite endpoint specifically designed to assess outcomes related to the treated coronary lesion in interventional cardiology trials. TLF combines three components: cardiac death, target vessel myocardial infarction (not clearly attributable to non-target vessels), and clinically-driven target lesion revascularization. This endpoint provides a lesion-focused assessment of treatment efficacy and safety, distinguishing events directly related to the index lesion from those occurring elsewhere in the coronary circulation. Target lesion failure has become a standard endpoint in percutaneous coronary intervention trials, particularly those evaluating drug-eluting stents and other interventional devices.
Usage
Usage note: Clearly distinguish from target vessel failure and specify lesion-level attribution criteria.
In Context
- "Target lesion failure rates were comparable between the two stent platforms at 12-month follow-up." — device comparison trial
- "The primary endpoint of target lesion failure occurred in 4.2% of patients in the treatment group." — clinical trial results