target lesion revascularization
Also written as: TLR — Target Lesion Revascularization
Any repeat revascularization procedure involving the originally treated lesion or within 5mm of its margins.
Full Definition
Target lesion revascularization (TLR) is defined as any repeat revascularization procedure, either percutaneous or surgical, involving the originally treated lesion or the vessel segment within 5 millimeters proximal or distal to the lesion margins. TLR is considered a marker of procedural failure and is commonly used as a secondary endpoint in cardiovascular device trials. The procedure may be clinically driven (performed for symptoms or objective evidence of ischemia) or non-clinically driven (performed based on angiographic findings alone without clinical symptoms). TLR rates provide important information about the long-term effectiveness of different interventional techniques and devices. The definition specifically focuses on the lesion level rather than the vessel level, allowing for more precise assessment of local treatment effects and complications such as restenosis or stent thrombosis.
Usage
Usage note: Distinguish between clinically driven and non-clinically driven TLR in study reports.
In Context
- "Target lesion revascularization was required in 6.8% of patients within 12 months." — Follow-up study results
- "The need for target lesion revascularization was significantly reduced in the drug-eluting stent group." — Comparative effectiveness study