Professional
Technical
In the Industry Vocabulary Test
cytological atypia
Abnormal cellular features observed on microscopic examination that deviate from normal cytological characteristics.
Full Definition
Cytological atypia encompasses a spectrum of cellular abnormalities including nuclear enlargement, pleomorphism, hyperchromasia, and altered nuclear-to-cytoplasmic ratios that suggest neoplastic transformation but fall short of definitive malignancy criteria. In thyroid cytopathology, atypia is categorized within the Bethesda system and often necessitates surgical evaluation for definitive diagnosis. The degree and pattern of atypia help pathologists risk-stratify lesions and guide clinical management decisions.
Usage
Usage note: Always specify the degree (mild, moderate, severe) and specific features to aid in clinical correlation.
In Context
- "The fine needle aspiration revealed cytological atypia with enlarged nuclei and prominent nucleoli." — Cytopathology report
- "Moderate cytological atypia was present but insufficient for a definitive diagnosis of malignancy." — Pathology consultation note
Also known as
cellular atypia
cytologic atypia
Contrasted with
cytological normalcy
Don't confuse with
malignancy
dysplasia