paraganglioma
Pronunciation: pair-uh-gang-glee-OH-muh
A rare neuroendocrine tumor arising from paraganglia in various body locations outside the adrenal medulla.
Full Definition
Paragangliomas are rare neuroendocrine tumors that develop from paraganglia, clusters of neuroendocrine cells located outside the adrenal medulla. These tumors can occur in various anatomical sites including the head, neck, thorax, abdomen, and pelvis. They may be functional (secreting catecholamines) or non-functional, and can be associated with hereditary syndromes. Paragangliomas are often discussed in contrast to pheochromocytomas, which arise specifically from the adrenal medulla. Clinical presentation varies by location and functional status, requiring careful diagnostic workup including biochemical testing and specialized imaging.
Usage
Usage note: Often confused with pheochromocytoma; distinguish by anatomical location (extra-adrenal vs. adrenal medulla).
In Context
- "The patient presented with a retroperitoneal paraganglioma measuring 4.2 cm on contrast-enhanced CT." — Radiology report
- "Genetic counseling was recommended given the familial paraganglioma syndrome suspected in this case." — Oncology consultation note