multiple endocrine neoplasia
Also written as: MEN — multiple endocrine neoplasia
Hereditary cancer syndromes characterized by tumors in multiple endocrine organs, requiring genetic counseling and screening.
Full Definition
Multiple endocrine neoplasia (MEN) comprises a group of autosomal dominant inherited disorders characterized by the development of tumors in multiple endocrine glands. MEN1 involves parathyroid, pituitary, and pancreatic islet tumors, while MEN2A includes medullary thyroid carcinoma, pheochromocytoma, and parathyroid adenomas. MEN2B features medullary thyroid carcinoma, pheochromocytoma, and distinctive physical findings including marfanoid habitus and mucosal neuromas. These syndromes require lifelong surveillance, genetic testing of family members, and often prophylactic surgery. Understanding MEN syndromes is crucial for endocrine surgeons as they influence timing and extent of surgical intervention.
Usage
Usage note: Commonly abbreviated as MEN; specify type (MEN1, MEN2A, MEN2B) when relevant.
In Context
- "The patient's family history of multiple endocrine neoplasia prompted genetic testing." — genetics consultation
- "Multiple endocrine neoplasia type 2B requires prophylactic thyroidectomy in early childhood." — pediatric surgery guideline