Lennox-Gastaut syndrome
Also written as: LGS — Lennox-Gastaut syndrome
A severe childhood epilepsy syndrome characterized by multiple seizure types, intellectual disability, and distinctive EEG patterns.
Full Definition
Lennox-Gastaut syndrome (LGS) is a severe childhood epileptic encephalopathy that typically begins between ages 1-8 years. It is characterized by a triad of multiple seizure types (particularly tonic, atonic, and atypical absence seizures), intellectual disability or developmental regression, and a characteristic EEG pattern of slow spike-and-wave complexes (1.5-2.5 Hz). The syndrome is often treatment-resistant and may be associated with various underlying brain abnormalities. Patients frequently require multiple antiseizure medications and may benefit from devices like vagus nerve stimulators or dietary therapies.
Usage
Usage note: Often abbreviated as LGS in clinical documentation.
In Context
- "The diagnosis of Lennox-Gastaut syndrome was confirmed by the presence of multiple seizure types and characteristic slow spike-wave on EEG." — Pediatric neurology consultation
- "Treatment options for Lennox-Gastaut syndrome include rufinamide and newer antiseizure medications specifically approved for this indication." — Treatment planning document