Levetiracetam
Pronunciation: /ˌlɛvɪˈtaɪrəsəˌtæm/
A broad-spectrum antiepileptic drug with a unique mechanism of action through synaptic vesicle protein 2A binding.
Full Definition
Levetiracetam is a second-generation antiepileptic drug that works through binding to synaptic vesicle protein 2A (SV2A), modulating neurotransmitter release. It is effective against both focal and generalized seizures and is available in oral and intravenous formulations. Levetiracetam has favorable pharmacokinetic properties including minimal protein binding, lack of hepatic enzyme interactions, and primarily renal elimination. Common side effects include somnolence, fatigue, and behavioral changes such as irritability or depression. The drug is often used as first-line therapy due to its broad efficacy and relatively benign side effect profile.
Usage
Usage note: Brand name Keppra commonly used in clinical practice.
In Context
- "Levetiracetam was initiated at 500 mg twice daily and titrated to seizure control." — Treatment plan
- "The patient developed behavioral side effects on levetiracetam requiring dose reduction." — Medication adjustment