FOLFIRINOX
Pronunciation: FOLL-fi-ri-noks
Also written as: FOLFIRINOX — folinic acid, 5-fluorouracil, irinotecan, oxaliplatin
An intensive chemotherapy regimen combining four drugs used primarily for advanced pancreatic cancer treatment.
Full Definition
FOLFIRINOX consists of folinic acid (leucovorin), 5-fluorouracil, irinotecan, and oxaliplatin administered in specific sequence and dosing. This aggressive multi-drug protocol has demonstrated superior efficacy compared to single-agent gemcitabine in metastatic pancreatic adenocarcinoma, though with increased toxicity profile. The regimen requires careful patient selection based on performance status and organ function. Editorial attention is needed for consistent capitalization and proper drug sequencing when detailed protocols are described.
Usage
Usage note: Always capitalize entirely; avoid confusion with similar regimen names (FOLFOX, FOLFIRI).
In Context
- "The patient tolerated six cycles of FOLFIRINOX with manageable grade 2 neuropathy." — Oncology progress note
- "FOLFIRINOX demonstrated superior overall survival compared to gemcitabine in the PRODIGE trial." — Clinical review article