signet ring cell carcinoma
Pronunciation: SIG-net ring sel kar-suh-NOH-muh
An aggressive histological subtype of adenocarcinoma characterized by mucin-filled cells with displaced nuclei, resembling signet rings.
Full Definition
Signet ring cell carcinoma represents a poorly differentiated variant of adenocarcinoma where malignant cells contain abundant intracytoplasmic mucin that displaces the nucleus to the cell periphery, creating the characteristic signet ring appearance under microscopic examination. This histological pattern is most commonly encountered in gastric cancer but can occur throughout the gastrointestinal tract. Signet ring cell histology typically indicates aggressive tumor behavior with higher propensity for peritoneal dissemination and poorer prognosis compared to conventional adenocarcinoma. Accurate identification requires expert pathological interpretation and may influence treatment planning.
Usage
Usage note: Use 'signet ring' (not 'signet-ring') as compound modifier; emphasize histological significance in context.
In Context
- "Histopathology revealed signet ring cell carcinoma with extensive lymphovascular invasion." — Pathology report
- "The presence of signet ring cell features portends a more aggressive clinical course." — Tumor board discussion