Professional
Technical
IVT
monoclonal protein
An abnormal protein produced by a clone of plasma cells, detected in serum or urine electrophoresis.
Full Definition
A monoclonal protein, also called an M-protein or paraprotein, is an immunoglobulin or immunoglobulin fragment produced by a single clone of abnormal plasma cells. It appears as a distinct peak on serum protein electrophoresis and can indicate various conditions from benign monoclonal gammopathy to multiple myeloma. The presence, type, and quantity of monoclonal proteins are crucial for diagnosing and monitoring plasma cell disorders and certain lymphomas.
Usage
Usage note: Often abbreviated as M-protein in clinical documentation; ensure consistent usage within documents.
In Context
- "Serum electrophoresis revealed a monoclonal protein of 2.3 g/dL in the gamma region." — Laboratory report
- "The presence of a monoclonal protein warranted further investigation for plasma cell dyscrasia." — Clinical progress note
Also known as
M-protein
paraprotein
M-spike
Contrasted with
polyclonal protein
Don't confuse with
monoclonal antibody
monoclonal gammopathy