thrombocytopenia
Pronunciation: throm-bo-cy-to-PEE-nee-ah
A condition characterized by an abnormally low platelet count in the peripheral blood, typically below 150,000 per microliter.
Full Definition
Thrombocytopenia refers to a reduced platelet count below the normal range, generally defined as less than 150,000 platelets per microliter of blood. In hematologic oncology, thrombocytopenia commonly results from decreased platelet production due to bone marrow suppression from chemotherapy, radiation, or malignant infiltration, though increased destruction or consumption may also occur. Clinical manifestations include petechiae, purpura, mucosal bleeding, and in severe cases, life-threatening hemorrhage. Platelet transfusion may be required when counts fall below 10,000-20,000/μL or in the presence of active bleeding.
Usage
Usage note: Often abbreviated as TCP in clinical notes. Severity classification varies by institution but generally: mild (100,000-150,000), moderate (50,000-100,000), severe (<50,000).
In Context
- "Severe thrombocytopenia necessitated platelet transfusion prior to the invasive procedure." — Pre-procedural assessment
- "The patient's thrombocytopenia resolved gradually following completion of chemotherapy." — Follow-up examination