myelosuppression
Pronunciation: MY-eh-low-suh-PRESH-un
Suppression of bone marrow function resulting in decreased production of blood cells, commonly caused by chemotherapy or radiation therapy.
Full Definition
Myelosuppression refers to the decreased activity of the bone marrow, leading to reduced production of blood cells including white blood cells, red blood cells, and platelets. This is a common and serious side effect of many cancer treatments, particularly chemotherapy and radiation therapy. The severity is graded and monitored closely, as it can lead to increased infection risk, anemia, and bleeding complications. Recovery typically occurs between treatment cycles but may require dose modifications or supportive care measures.
Usage
Usage note: Always specify the grade when describing severity in clinical contexts.
In Context
- "The patient experienced grade 3 myelosuppression requiring a treatment delay." — Clinical trial report
- "Myelosuppression was the dose-limiting toxicity observed in the phase I study." — Research publication