glioblastoma multiforme
Also written as: GBM — Glioblastoma Multiforme
The most aggressive primary brain tumor, requiring precise editorial handling of its complex staging and treatment terminology.
Full Definition
Glioblastoma multiforme (GBM) is the most common and aggressive form of primary brain cancer in adults, classified as a Grade IV astrocytoma. It presents unique editorial challenges due to its rapidly evolving treatment protocols, complex molecular classifications, and the need for precise terminology when describing survival statistics and quality-of-life measures. Editors must distinguish between newly diagnosed and recurrent cases, understand the significance of MGMT methylation status, and accurately present clinical trial data.
Usage
Usage note: Always specify 'newly diagnosed' or 'recurrent' when context allows; avoid using 'GBM' on first reference without expansion.
In Context
- "The patient's glioblastoma multiforme showed IDH-wildtype characteristics with unmethylated MGMT promoter status." — Clinical research report
- "Standard-of-care treatment for newly diagnosed GBM includes maximal safe resection followed by concurrent chemoradiotherapy." — Treatment protocol documentation