glioma-associated seizures
Epileptic seizures that occur as a consequence of brain tumor growth and its effects on surrounding neural tissue.
Full Definition
Glioma-associated seizures are epileptic events that develop as a direct result of brain tumor presence and growth. These seizures occur in 60-90% of patients with low-grade gliomas and 30-50% of those with high-grade gliomas, often presenting as the initial symptom that leads to tumor diagnosis. The mechanisms include direct cortical irritation, altered neurotransmitter balance, metabolic changes, and disruption of normal neural networks. Seizure characteristics depend on tumor location, with temporal lobe tumors commonly causing complex partial seizures and frontal tumors causing motor seizures. Management requires both antiepileptic drugs and tumor-directed therapy, as seizure control often correlates with tumor growth control.
Usage
Usage note: Hyphenate when used as a compound adjective before a noun.
In Context
- "The patient's glioma-associated seizures improved following initiation of levetiracetam." — Neurology clinic note
- "Glioma-associated seizures were the presenting symptom in 80% of our low-grade glioma patients." — Research publication