gliomatosis cerebri
A rare diffuse glioma growth pattern characterized by extensive infiltration of multiple brain regions while preserving normal architecture.
Full Definition
Gliomatosis cerebri represents a distinct growth pattern of diffuse gliomas characterized by widespread infiltration of glial tumor cells throughout multiple brain regions, often involving both cerebral hemispheres, while maintaining the underlying brain architecture. This pattern can be seen with various glioma types, including astrocytomas and oligodendrogliomas of different grades. The condition typically presents with subtle neurological deficits, personality changes, or cognitive decline rather than focal symptoms. Diagnosis relies heavily on advanced imaging techniques, particularly FLAIR MRI sequences that demonstrate extensive T2 hyperintensity. Treatment is challenging due to the diffuse nature, often requiring radiation therapy and chemotherapy rather than surgical intervention.
Usage
Usage note: Term describes growth pattern, not a specific tumor type.
In Context
- "FLAIR imaging revealed the characteristic pattern of gliomatosis cerebri spanning both hemispheres." — Radiology report
- "The patient's subtle cognitive decline was ultimately attributed to gliomatosis cerebri." — Clinical assessment