Molecular Subtype
Classification of brain tumors based on specific genetic and molecular characteristics rather than histological appearance alone.
Full Definition
Molecular subtype represents a modern approach to brain tumor classification that categorizes tumors based on their genetic and epigenetic profiles rather than solely on microscopic appearance. Key molecular markers include IDH mutation status, 1p/19q codeletion, MGMT methylation, and various other genetic alterations that influence prognosis and treatment selection. This molecular classification has been integrated into the WHO classification system, leading to more precise diagnoses and personalized treatment approaches. Molecular subtyping often overrides traditional histological classifications when there are discrepancies.
Usage
Usage note: Specify the key molecular markers that define the subtype when mentioned.
In Context
- "The molecular subtype indicated an IDH-mutant, 1p/19q-codeleted oligodendroglioma with favorable prognosis." — Pathology report
- "Treatment selection was based on the tumor's molecular subtype rather than histological features alone." — Tumor board discussion