molecular tumor board
Also written as: MTB
A multidisciplinary conference that incorporates comprehensive molecular profiling data to guide personalized treatment decisions for brain tumor patients.
Full Definition
A molecular tumor board is a specialized multidisciplinary conference that integrates comprehensive molecular and genetic profiling data with traditional clinical and pathological information to guide personalized treatment decisions for brain tumor patients. These boards typically include neuro-oncologists, neurosurgeons, radiation oncologists, molecular pathologists, geneticists, and bioinformaticians who collectively review complex cases where molecular findings may influence therapeutic approaches. The molecular tumor board concept has become increasingly important with the incorporation of molecular markers into brain tumor classification and the development of targeted therapies. These conferences are particularly valuable for rare tumors, treatment-resistant cases, or when molecular findings suggest novel therapeutic opportunities through clinical trials or off-label drug use.
Usage
Usage note: Increasingly standard in academic medical centers; reflects evolution of personalized medicine.
In Context
- "The molecular tumor board recommended targeted therapy based on the patient's rare fusion variant identified through comprehensive genomic profiling." — Treatment recommendation
- "Following molecular tumor board review, the patient was enrolled in a precision medicine clinical trial targeting their specific genetic alteration." — Clinical trial enrollment