Stupp protocol
The standard treatment regimen for newly diagnosed glioblastoma combining radiation therapy with temozolomide.
Full Definition
The Stupp protocol, named after Roger Stupp, is the standard-of-care treatment for newly diagnosed glioblastoma multiforme. It consists of concurrent chemoradiotherapy using temozolomide followed by adjuvant temozolomide cycles. The protocol demonstrated significant survival benefit in the landmark EORTC-NCIC trial and remains the foundation for most glioblastoma treatment approaches. Editors must understand the specific phases of treatment, duration, and how modifications or combinations with other therapies are described in clinical literature.
Usage
Usage note: Capitalize 'Stupp' as it derives from the physician's name; may be used interchangeably with 'standard-of-care' in glioblastoma contexts.
In Context
- "All patients received the Stupp protocol with concurrent temozolomide and radiation therapy." — Clinical study methods
- "The experimental agent was added to standard Stupp protocol in the combination arm." — Clinical trial design description