subependymal giant cell astrocytoma
Also written as: SEGA — subependymal giant cell astrocytoma
A WHO Grade I tumor that occurs almost exclusively in patients with tuberous sclerosis complex, typically arising near the foramen of Monro.
Full Definition
Subependymal giant cell astrocytoma (SEGA) is a rare, WHO Grade I brain tumor that develops almost exclusively in patients with tuberous sclerosis complex (TSC). These tumors typically arise from subependymal nodules near the foramen of Monro and are characterized by large, bizarre cells with abundant cytoplasm. Despite their benign histological grade, SEGAs can cause significant clinical problems due to their location, potentially leading to obstructive hydrocephalus. The tumors are often slow-growing but may require intervention if they cause ventricular obstruction or show progressive growth. Treatment options include surgical resection and targeted therapy with mTOR inhibitors such as everolimus.
Usage
Usage note: Acronym SEGA is widely used; always associated with tuberous sclerosis complex.
In Context
- "Serial MRI demonstrated progressive enlargement of the subependymal giant cell astrocytoma with early signs of ventricular dilatation." — Radiology report
- "The patient's subependymal giant cell astrocytoma showed excellent response to everolimus therapy with significant tumor shrinkage." — Follow-up note