tumor treating fields therapy
Electromagnetic field treatment modality that disrupts cancer cell division through alternating electric fields.
Full Definition
Tumor treating fields (TTFields) therapy is a novel treatment modality that uses low-intensity, intermediate-frequency alternating electric fields to disrupt cellular processes essential for cancer cell division. The treatment involves wearing arrays of electrodes on the scalp that deliver these fields directly to the tumor region. TTFields therapy has been approved for glioblastoma treatment based on clinical trials showing improved survival when combined with standard chemotherapy. The mechanism involves interference with microtubule function during mitosis, selectively affecting rapidly dividing cancer cells while sparing normal tissue. The therapy requires continuous application for at least 18 hours daily to achieve optimal efficacy.
Usage
Usage note: May be abbreviated as TTFields therapy. Always specify as therapy when using the full term.
In Context
- "The patient was initiated on tumor treating fields therapy following completion of radiation therapy." — Treatment plan
- "Compliance with TTFields therapy was excellent at 22 hours per day." — Follow-up visit note