vincristine-induced peripheral neuropathy
Also written as: VIPN — Vincristine-Induced Peripheral Neuropathy
Dose-limiting neurotoxic side effect of vincristine chemotherapy causing numbness and weakness in extremities.
Full Definition
Vincristine-induced peripheral neuropathy (VIPN) is a common and dose-limiting toxicity of vincristine, a vinca alkaloid frequently used in pediatric brain tumor protocols. The neuropathy results from microtubule disruption in peripheral nerves and typically presents as distal sensorimotor symptoms including numbness, tingling, and weakness beginning in the feet and hands. Symptoms usually develop after cumulative doses and may progress to significant functional impairment if treatment continues. The neuropathy can be partially reversible but may persist long-term, particularly in children who received high cumulative doses. Recognition and appropriate dose modification are essential to prevent severe and potentially permanent neurological dysfunction.
Usage
Usage note: Can be abbreviated as VIPN in clinical documentation. Hyphenate when used as compound modifier.
In Context
- "The patient developed grade 2 vincristine-induced peripheral neuropathy requiring dose reduction." — Oncology progress note
- "Long-term follow-up revealed persistent vincristine-induced peripheral neuropathy in 30% of survivors." — Survivorship clinic assessment