Intermediate
Technical
IVT
neurosecretory dysfunction
Impaired synthesis, transport, or release of neuropeptides and neurohormones from neuroendocrine cells.
Full Definition
Neurosecretory dysfunction encompasses a spectrum of disorders characterized by abnormal production, processing, or secretion of neurohormones and neuropeptides. This can result from genetic defects in hormone synthesis, disrupted axonal transport, impaired exocytotic machinery, or damage to neuroendocrine neurons. The dysfunction may be selective for specific hormones or affect multiple neuroendocrine pathways simultaneously. Clinical manifestations depend on which neurosecretory systems are affected and may include disorders of growth, reproduction, water balance, or stress response.
In Context
- "The patient's growth retardation was attributed to neurosecretory dysfunction affecting growth hormone release." — clinical case report
- "Genetic testing revealed mutations associated with congenital neurosecretory dysfunction." — diagnostic report
Also known as
neuroendocrine dysfunction
neurosecretory impairment
Contrasted with
normal neurosecretion
Don't confuse with
neurotransmitter dysfunction
endocrine dysfunction