Professional
Technical
IVT
anti-AQP4 antibodies
Autoantibodies targeting aquaporin-4 water channels, pathognomonic for neuromyelitis optica spectrum disorder.
Full Definition
Autoantibodies directed against aquaporin-4 water channels found on astrocyte end-feet at the blood-brain barrier. These antibodies are highly specific for neuromyelitis optica spectrum disorder (NMOSD) and are used as a key diagnostic biomarker. The presence of anti-AQP4 antibodies distinguishes NMOSD from multiple sclerosis and guides treatment decisions. Testing is typically performed using cell-based assays for optimal sensitivity and specificity.
Usage
Usage note: Always hyphenate 'anti-AQP4' when referring to the antibodies specifically.
In Context
- "The patient tested positive for anti-AQP4 antibodies, confirming the diagnosis of neuromyelitis optica spectrum disorder." — Laboratory report
- "Anti-AQP4 antibody seropositivity was associated with more severe relapses and worse visual outcomes." — Clinical research paper
Also known as
AQP4 antibodies
aquaporin-4 antibodies
NMO-IgG
Don't confuse with
anti-MOG antibodies
oligoclonal bands