CXCL13
A B-cell-attracting chemokine elevated in cerebrospinal fluid during active neuroinflammation.
Full Definition
CXCL13 is a chemokine that attracts B cells and is significantly elevated in cerebrospinal fluid during periods of active central nervous system inflammation. It serves as a biomarker for intrathecal B-cell activity and is particularly useful in monitoring disease activity in multiple sclerosis and other neuroimmunological conditions. The presence of elevated CXCL13 in CSF indicates ongoing immune activation within the central nervous system. Clinical editors should note that CXCL13 levels can help distinguish between relapsing and progressive disease phases.
Usage
Usage note: Always capitalize as CXCL13; avoid confusion with other chemokine designations.
In Context
- "Elevated CXCL13 levels in the cerebrospinal fluid correlated with gadolinium-enhancing lesions on MRI." — Research paper
- "The patient's CXCL13 concentration suggested active intrathecal B-cell recruitment." — Clinical case report