IRIS
Pronunciation: EYE-ris
Also written as: IRIS — Immune Reconstitution Inflammatory Syndrome
Immune reconstitution inflammatory syndrome, a paradoxical worsening of neurological symptoms following immune system restoration.
Full Definition
Immune Reconstitution Inflammatory Syndrome (IRIS) in neurology refers to a paradoxical clinical deterioration that occurs when the immune system recovers and mounts an inflammatory response against previously controlled pathogens or self-antigens. This phenomenon is commonly seen in HIV patients starting antiretroviral therapy but can also occur in other immunocompromised states. In the neurological context, IRIS can manifest as worsening of opportunistic CNS infections, progressive multifocal leukoencephalopathy, or even autoimmune conditions as immune function is restored.
Usage
Usage note: Specify 'CNS-IRIS' when referring specifically to neurological manifestations.
In Context
- "The patient developed neurological IRIS three weeks after initiating highly active antiretroviral therapy." — HIV neurology case
- "Corticosteroids were considered to manage the inflammatory component of CNS-IRIS." — Treatment plan