neurofilament light chain
A protein biomarker released from damaged neurons that indicates axonal injury in neurological diseases.
Full Definition
Neurofilament light chain (NfL) is a structural protein component of neuronal axons that is released into cerebrospinal fluid and blood following axonal damage. It serves as a highly sensitive biomarker of neuroaxonal injury across various neurological conditions, including multiple sclerosis, neurodegenerative diseases, and inflammatory CNS disorders. NfL levels correlate with disease severity and progression, making it valuable for monitoring treatment response and predicting clinical outcomes. The protein can be measured in both cerebrospinal fluid and serum, with serum levels becoming increasingly important for non-invasive monitoring.
Usage
Usage note: Commonly abbreviated as NfL or NFL; ensure consistency within documents.
In Context
- "Serum neurofilament light chain levels were significantly elevated in patients with active multiple sclerosis." — Clinical study
- "The decrease in NfL concentration following treatment initiation suggested reduced axonal damage." — Treatment monitoring report