neurogenic inflammation
Inflammatory response initiated and maintained by the nervous system through neuropeptide release and neural signaling.
Full Definition
Neurogenic inflammation refers to a localized inflammatory response that is initiated, maintained, or modulated by the nervous system, particularly through the release of neuropeptides and other inflammatory mediators from nerve terminals. This process involves the interaction between sensory neurons, immune cells, and vascular elements, creating a complex inflammatory cascade. In neuroimmunological conditions, neurogenic inflammation can contribute to disease progression, symptom severity, and treatment resistance. Understanding this mechanism has important implications for developing targeted therapies in neuroinflammatory diseases.
Usage
Usage note: Emphasize the neural origin when distinguishing from other inflammatory mechanisms.
In Context
- "The patient's symptoms suggested a component of neurogenic inflammation contributing to disease severity." — Pathophysiology discussion
- "Targeting neurogenic inflammation pathways may provide additional therapeutic benefit." — Treatment strategy