Intermediate
Technical
IVT
perinuclear halo
A clear zone around the nucleus in neurons, often indicating cellular pathology or fixation artifact.
Full Definition
A perinuclear halo refers to a clear, unstained area surrounding the neuronal nucleus, creating a ring-like appearance. This finding can result from various causes including fixation artifacts, osmotic changes, or genuine pathological processes such as viral infections or metabolic disorders. In some cases, it may represent displacement of organelles away from the nucleus. The presence and pattern of perinuclear halos can provide diagnostic clues in neuropathological examination.
Usage
Usage note: Distinguish between pathological and artifactual causes.
In Context
- "Many cortical neurons displayed prominent perinuclear halos, raising concern for viral encephalitis." — Brain biopsy report
- "The perinuclear halos observed were likely artifactual given the prolonged fixation time." — Quality control note
Also known as
perinuclear clearing
nuclear halo
Don't confuse with
artifact
vacuolation