perivascular inflammation
Accumulation of inflammatory cells around blood vessels in brain tissue, indicating neuroinflammatory processes.
Full Definition
Perivascular inflammation refers to the collection of inflammatory cells, primarily lymphocytes and macrophages, in the spaces surrounding brain blood vessels. This pattern is characteristic of various neuroinflammatory conditions including viral encephalitis, multiple sclerosis, autoimmune encephalitis, and some neurodegenerative diseases. The inflammation typically begins in the perivascular (Virchow-Robin) spaces and can extend into adjacent brain parenchyma. The cellular composition and distribution of perivascular inflammation can provide important diagnostic information about the underlying pathological process.
Usage
Usage note: Describe the cellular composition when known from immunostaining.
In Context
- "Extensive perivascular inflammation was noted throughout the white matter, suggesting viral encephalitis." — Brain biopsy report
- "The perivascular inflammation consisted predominantly of CD3-positive T lymphocytes." — Immunohistochemistry findings