perivascular lymphocytic cuffing
Inflammatory infiltrate of lymphocytes surrounding blood vessels in the CNS parenchyma.
Full Definition
Perivascular lymphocytic cuffing refers to the accumulation of inflammatory cells, predominantly lymphocytes, around blood vessels within the central nervous system. This pattern is characteristic of various neuroinflammatory conditions including viral encephalitis, multiple sclerosis, and autoimmune encephalitides. The lymphocytic infiltrate typically extends from the perivascular space into the adjacent neuropil, creating a characteristic 'cuffing' appearance on histological examination. The severity and distribution of cuffing can provide diagnostic clues about the underlying pathological process.
Usage
Usage note: Specify lymphocyte predominance to distinguish from other inflammatory infiltrates.
In Context
- "Extensive perivascular lymphocytic cuffing was noted throughout the white matter." — Multiple sclerosis biopsy report
- "The viral encephalitis case demonstrated prominent perivascular lymphocytic cuffing in the temporal cortex." — Autopsy report