Gliadel wafer
Pronunciation: GLEE-ah-del
Biodegradable polymer wafer containing carmustine chemotherapy, implanted in the tumor cavity during surgery.
Full Definition
Gliadel wafers are biodegradable polymer discs impregnated with carmustine (BCNU), a chemotherapy agent used in treating malignant gliomas. These wafers are placed directly into the tumor resection cavity during surgery, where they slowly release chemotherapy over several weeks as the polymer dissolves. This local delivery method allows high concentrations of drug at the tumor site while minimizing systemic toxicity. The wafers are FDA-approved for newly diagnosed and recurrent malignant glioma, though their use has declined with advances in other treatment modalities.
Usage
Usage note: Always capitalize as it is a proprietary drug name. Specify number of wafers implanted in operative reports.
In Context
- "Eight Gliadel wafers were placed in the resection cavity following gross total resection of the glioblastoma." — Operative report
- "The patient developed delayed wound healing, a known complication of Gliadel wafer placement." — Postoperative complication note