Advanced
Technical
IVT
optic nerve invasion
Extension of intraocular tumor into the optic nerve, representing high-risk feature requiring aggressive treatment. Critical staging parameter in retinoblastoma.
Full Definition
The extension of malignant cells from an intraocular tumor, particularly retinoblastoma, into the optic nerve tissue beyond the lamina cribrosa. Optic nerve invasion is classified by depth of involvement and represents a high-risk feature associated with increased metastatic potential and mortality. Detection requires careful histopathological examination and significantly influences staging, prognosis, and the need for adjuvant chemotherapy in retinoblastoma management.
Usage
Usage note: Specify extent of invasion (pre-laminar, post-laminar, resection margin) in pathology documentation.
In Context
- "Histopathological examination revealed optic nerve invasion extending 5mm beyond the globe." — pathology report
- "The presence of optic nerve invasion necessitated adjuvant chemotherapy." — treatment planning note
Also known as
optic nerve infiltration
nerve involvement
Don't confuse with
optic nerve atrophy
optic disc swelling