systemic inflammatory response syndrome
Body's inflammatory response to severe physiological stress, often following major oncologic surgery.
Full Definition
Systemic inflammatory response syndrome (SIRS) is a widespread inflammatory cascade that can occur following major surgical procedures, particularly extensive oncologic resections. It is characterized by specific physiological criteria including altered temperature, heart rate, respiratory rate, and white blood cell count. In the context of oncologic surgery, SIRS may develop due to the magnitude of surgical trauma, tumor burden, or complications such as infection. Recognition and management of SIRS is crucial as it can progress to multiple organ dysfunction and sepsis if left untreated.
Usage
Usage note: Often abbreviated as SIRS; distinguish from sepsis which requires evidence of infection.
In Context
- "The patient developed systemic inflammatory response syndrome on postoperative day two following extensive hepatectomy." — Progress note
- "Monitoring for systemic inflammatory response syndrome is essential after major cytoreductive procedures." — Clinical protocol