bisphosphonate-related osteonecrosis
A condition where jaw bone tissue dies due to bisphosphonate medication use, often triggered by dental procedures.
Full Definition
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a serious adverse reaction to bisphosphonate medications characterized by exposed, necrotic bone in the oral cavity that persists for more than 8 weeks. The condition most commonly affects the mandible and is often triggered by dental extractions or trauma. Bisphosphonates impair bone remodeling and healing by affecting osteoclast function. Prevention involves careful dental screening before bisphosphonate therapy and conservative dental management in patients taking these medications.
Usage
Usage note: Now more commonly termed 'medication-related osteonecrosis' (MRONJ) to include other antiresorptive agents.
In Context
- "The patient developed bisphosphonate-related osteonecrosis following extraction of the mandibular molar." — Complication documentation
- "Conservative management was chosen for the BRONJ lesion to avoid further bone exposure." — Treatment planning note