Protein-Losing Enteropathy
A serious complication of Fontan circulation characterized by excessive loss of proteins through the gastrointestinal tract.
Full Definition
Protein-losing enteropathy (PLE) is a severe late complication following Fontan operation, characterized by increased intestinal permeability leading to excessive protein loss into the gastrointestinal tract. This condition results in hypoproteinemia, edema, ascites, and malnutrition. The elevated central venous pressure associated with Fontan physiology is thought to contribute to intestinal lymphatic congestion and subsequent protein loss. Management includes dietary modifications, medical therapy, and occasionally surgical revision. PLE carries significant morbidity and mortality.
Usage
Usage note: Always spelled with hyphens; commonly abbreviated as PLE in clinical notes.
In Context
- "The patient developed protein-losing enteropathy five years after Fontan completion." — Complication report
- "Protein-losing enteropathy was suspected based on hypoalbuminemia and peripheral edema." — Clinical assessment