hypogonadotropic hypogonadism
Pronunciation: hahy-poh-gon-uh-doh-TROH-pik hahy-poh-GOH-nuh-diz-uhm
Condition where low gonadotropin levels lead to reduced sex hormone production and delayed or absent pubertal development.
Full Definition
Hypogonadotropic hypogonadism is an endocrine disorder characterized by deficient production of gonadotropins (LH and FSH) by the anterior pituitary gland, resulting in decreased stimulation of the gonads and consequently low sex hormone production. This condition can be congenital (such as Kallmann syndrome) or acquired (due to pituitary tumors, trauma, or infections). In pediatric patients, it typically presents as delayed or absent puberty, with lack of secondary sexual characteristics development, small genitalia, and in severe cases, lack of pubertal growth spurt. Diagnosis involves measuring low gonadotropin levels in the setting of low sex hormones. Treatment usually involves hormone replacement therapy to induce and maintain sexual development and may include fertility treatments in adulthood.
Usage
Usage note: Distinguish from primary hypogonadism; may be abbreviated as HH in subsequent references.
In Context
- "Hypogonadotropic hypogonadism was suspected when the 16-year-old showed no signs of pubertal development." — Adolescent medicine consultation
- "MRI imaging is recommended to evaluate for pituitary abnormalities in hypogonadotropic hypogonadism." — Diagnostic protocol