bone marrow aspirate
Liquid sample of bone marrow obtained through needle aspiration, used for cytological analysis and flow cytometry in pediatric hematologic disorders.
Full Definition
A bone marrow aspirate is a liquid sample of bone marrow obtained by inserting a needle into the bone marrow space, typically from the posterior iliac crest in children. The aspirate contains bone marrow cells suspended in blood and is essential for diagnosing hematologic malignancies, bone marrow failure syndromes, and other blood disorders in pediatric patients. Unlike a bone marrow biopsy, which provides architectural information, the aspirate allows for detailed morphological examination of individual cells, cytogenetic analysis, and flow cytometric studies. The procedure requires conscious sedation or general anesthesia in pediatric patients.
Usage
Usage note: Often performed concurrently with bone marrow biopsy; distinguish between aspirate (liquid) and biopsy (solid tissue).
In Context
- "The bone marrow aspirate revealed 85% blast cells, confirming the diagnosis of acute leukemia." — Pathology report
- "A bone marrow aspirate and biopsy were scheduled to evaluate the child's persistent cytopenia." — Procedure consent form