central line-associated bloodstream infection
A serious complication in immunocompromised pediatric hematology patients with central venous catheters. Often abbreviated as CLABSI.
Full Definition
Central line-associated bloodstream infection (CLABSI) is a laboratory-confirmed bloodstream infection in patients with central venous catheters where the infection is not related to another identifiable source. In pediatric hematology-oncology patients, CLABSIs pose significant risks due to underlying immunosuppression from chemotherapy or underlying disease. These infections can be caused by bacteria or fungi and may originate from catheter hub contamination, skin flora migration, or hematogenous seeding. Prevention strategies include strict aseptic technique during catheter insertion and maintenance, regular assessment of line necessity, and proper hub disinfection. Treatment typically involves systemic antibiotics and may require catheter removal depending on the organism and clinical response.
Usage
Usage note: Commonly abbreviated as CLABSI; ensure distinction from simple catheter colonization.
In Context
- "The patient developed a CLABSI with coagulase-negative staphylococcus." — infectious disease consultation
- "Prevention of central line-associated bloodstream infections requires strict sterile technique." — nursing protocol