cytarabine
Pronunciation: sy-TAIR-uh-been
A chemotherapy agent that is a cornerstone of acute leukemia treatment in children. Also known as ara-C.
Full Definition
Cytarabine (cytosine arabinoside, ara-C) is an antimetabolite chemotherapy drug that interferes with DNA synthesis by inhibiting DNA polymerase. It is a fundamental component of treatment protocols for pediatric acute myeloid leukemia and some forms of acute lymphoblastic leukemia. The drug is typically administered intravenously and can be given as standard-dose or high-dose regimens. High-dose cytarabine is particularly effective for central nervous system penetration. Common side effects include myelosuppression, nausea, and with high doses, cerebellar toxicity. The drug requires careful monitoring of complete blood counts and neurological function during administration.
Usage
Usage note: Commonly abbreviated as ara-C; distinguish from other similarly named chemotherapy agents.
In Context
- "The patient received high-dose cytarabine consolidation therapy for AML." — treatment protocol
- "Neurological examination was performed daily during cytarabine administration." — nursing notes