hemolytic-uremic syndrome
Also written as: HUS — hemolytic-uremic syndrome
A condition characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury, often following infection in children.
Full Definition
Hemolytic-uremic syndrome (HUS) is a serious condition primarily affecting young children, characterized by the triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury. The most common form is typical HUS, often triggered by Shiga toxin-producing Escherichia coli infections. Atypical HUS may be associated with complement system abnormalities or other triggers. Clinical presentation includes pallor, decreased urine output, edema, and sometimes neurologic symptoms. Laboratory findings show fragmented red blood cells (schistocytes), low platelet count, and elevated creatinine. Treatment is primarily supportive, with plasma exchange reserved for atypical cases or severe presentations.
Usage
Usage note: Commonly abbreviated as HUS; distinguish between typical and atypical forms.
In Context
- "The 3-year-old patient developed hemolytic-uremic syndrome following a bloody diarrheal illness caused by E. coli O157:H7." — Hospital discharge summary